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AACS cDNA ORF Clone in Cloning Vector, Human [BY-P-13621]

Cat. No.: BY-P-13621
Size: 1 Unit
Transportation: Each tube contains lyophilized plasmid.
Storage: Store at -20℃ for 2 years
Product Detail
Documents

Gene Information

Gene Name
AACS
Species
Human
Gene Length
2019 bp
Product Feature
Full length Clone DNA of Human acetoacetyl-CoA synthetase.
Sequence Signature
Identical with the Gene Bank Ref. ID sequence except for the point mutation 1929C/T not causing the amino acid variation.


Plasmid Information

Vector
pMD18-T Simple Vector
Sequencing Primer
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Bacterial Screening Resistance
Ampicillin


Background

Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter activity in 3T3-L1 adipocytes. Moreover, AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis. AACS gene expression is particularly abundant in white adipose tissue, as it is induced during adipocyte differentiation. The human AACS promoter is a PPARgamma target gene and that this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1 (stimulating protein-1). The Acetoacetyl-CoA Synthetase has important roles in the regulation of ketone body utilization in rat liver and that these hypocholesterolemic agents have the ability to remedy the impaired utilization of ketone bodies under the diabetic condition.

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