The products of our company are only used for external research, not for clinical diagnosis
0086-27-65522046
Collection
|

A33 cDNA ORF Clone in Cloning Vector, Human [BY-P-10372]

Cat. No.: BY-P-10372
Size: 1 Unit
Transportation: Each tube contains lyophilized plasmid.
Storage: Store at -20℃ for 2 years
Product Detail
Documents

Gene Information

Gene Name
A33
Species
Human
Gene Length
960 bp
Product Feature
Full length Clone DNA of Human glycoprotein A33 (transmembrane).
Sequence Signature
Identical with the Gene Bank Ref. ID sequence.


Plasmid Information

Vector
pMD18-T Simple Vector
Sequencing Primer
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Bacterial Screening Resistance
Ampicillin


Background

Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I membrane protein that is expressed in the normal gastrointestinal epithelium and 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.

Cancer Immunotherapy

Immune Checkpoint

Immunotherapy

Targeted Therapy

Email
*
up
to get resources and special offers
About us
Sales:Sales@beyoscience.com
Service:Service@beyoscience.com
Tel:0086-27-65522046
Floor 5, Building B1, Optics Valley Biological City, No. 666 Gaoxin Avenue, East Lake New Technology Development Zone, Wuhan
24-Hour Service
Worldwide Delivery
One Stop Procurement
Free Sample